This peptide is derived from the tumor associated antigen, NY-ESO-1, a commonly expressed tumor antigen of the cancer-testis family. The sequence for this peptide is SLLMWITQC from residues 157-165 and it binds to HLA-A*02:01.
Expression of HER2/neu (HER2) is increased in several cancers including breast, lung and colorectal cancers. This peptide represents residues 369-377 and has the sequence of KIFGSLAFL. It binds to HLA-A*02:01
Description: M1 peptide is a synthetic peptide represents residues 58-66 of the influenza A matrix protein. In HLA-A*0201 subjects the CD8+ CTL response is dominated by cells expressing Vβ17 and responding to this peptide. Structure: The sequence of the peptide is GILGFVFTL Storage: Store frozen at ≤minus 20oC Activity: The optimum concentration depends on the specific use of the peptide. To stimulate PBMC, concentrations of 1-10 ug/mL are appropriate. Specific T cell clones and lines respond well to much lower concentrations. References Moss PA, Moots RJ, Rosenberg WM, et al. (1991) Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. Natl Acad. Sci. 88:8987. Lehner PJ, Wang EC, Moss PA, et al. (1995) Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza is dominated by T cells bearing the V beta 17 gene segment. J Exp Med. 181:79
This peptide represents residues 84-97 of human myelin basic protein. This sequence has been shown to bind to multiple HLA-DR alleles and is thought to be the immunodominant peptide of MBP. The sequence is VVHFFKNIVTPRTP
Proinsulin is considered an important autoantigen in type 1 diabetes (T1D). Autoreactivity to Proinsulin is very common in T1D patients with the HLA-DRB1*0401 haplotype. The Proinsulin 73-90 peptide (GAGSLQPLALEGSLQKRG) has been identified as an immunodominant T cell epitope of HLA-DRB1*0401 subjects with beta-islet cell autoimmunity.
A tetanus toxoid peptide that has been described as universally immunogenic, QYIKANSKFIGITEL is recognized by a T cell line also available from Astarte Biologics. The T cell line is found at our Antigen Specific T cells Page. The original publication in the European Journal of Immunology can be found at the publishers website