Human Antigens

CMV antigens are enriched from a culture of CMV infected human fibroblasts by centrifugation on a sucrose gradient. There are multiple viral proteins present.

A peptide that binds to HLA-A*0201 and is derived from CMV, the sequence of this peptide is NLVPMVATV. See the antigen specific T cell page for the T cells that are reactive to this epitope.

Glutamic acid decarboxylase is an important autoantigen in diabetes. The sequence of this peptide is NFFRMVISNPAAT.

Expression of HER2/neu (HER2) is increased in several cancers including breast, lung and colorectal cancers. This peptide represents residues 369-377 and has the sequence of KIFGSLAFL. It binds to HLA-A*02:01

This peptide binds to HLA-A*02:01 molecules and can be used to stimulate our HPV specific T cells that recognize this epitope. The sequence is YMLDLQPETT.

This peptide is derived from the E7 protein of HPV type 16 and has the sequence YMLDLQPET. We also provide the peptide representing residues 11-20 so be sure the peptide you intend to purchase.

A peptide from the E7 protein of HPV, residues 82-90. The sequence is LLMGTLGIV.

This peptide is derived from glycoprotein D of the herpes simplex virus. It binds to HLA-A*02:01 and is recognized by anti HSV T cells sold by Astarte Biologics.

Description: M1 peptide is a synthetic peptide represents residues 58-66 of the influenza A matrix protein. In HLA-A*0201 subjects the CD8+ CTL response is dominated by cells expressing Vβ17 and responding to this peptide. Structure: The sequence of the peptide is GILGFVFTL Storage: Store frozen at ≤minus 20oC Activity: The optimum concentration depends on the specific use of the peptide. To stimulate PBMC, concentrations of 1-10 ug/mL are appropriate. Specific T cell clones and lines respond well to much lower concentrations. References Moss PA, Moots RJ, Rosenberg WM, et al. (1991) Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc. Natl Acad. Sci. 88:8987. Lehner PJ, Wang EC, Moss PA, et al. (1995) Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza is dominated by T cells bearing the V beta 17 gene segment. J Exp Med. 181:79

MAGE-A10 is a tumor antigen of the cancer-testes family. This peptide has the sequence GLYDGMEHL and is recognized by our anti MAGE-A10 T cells.

This peptide represents residues 84-97 of human myelin basic protein. This sequence has been shown to bind to multiple HLA-DR alleles and is thought to be the immunodominant peptide of MBP. The sequence is VVHFFKNIVTPRTP

This peptide is derived from the tumor associated antigen, NY-ESO-1, a commonly expressed tumor antigen of the cancer-testis family. The sequence for this peptide is SLLMWITQC from residues 157-165 and it binds to HLA-A*02:01.

Proinsulin is considered an important autoantigen in type 1 diabetes (T1D). Autoreactivity to Proinsulin is very common in T1D patients with the HLA-DRB1*0401 haplotype. The Proinsulin 73-90 peptide (GAGSLQPLALEGSLQKRG) has been identified as an immunodominant T cell epitope of HLA-DRB1*0401 subjects with beta-islet cell autoimmunity.

This peptide (KLPDDFTGCV) corresponds to the SARS-CoV2 Spike (S) protein at amino acid positions 424-433. It is predicted to bind preferentially to HLA-A*0201.

A tetanus toxoid peptide that has been described as universally immunogenic, QYIKANSKFIGITEL is recognized by a T cell line also available from Astarte Biologics. The T cell line is found at our Antigen Specific T cells Page. The original publication in the European Journal of Immunology can be found at the publishers website

Description:
Tetanus toxoid is an inactivated form of tetanus toxin. Tetanus toxin is an exotoxin produced by Clostridium tetani and is the agent responsible for “lockjaw”;. Tetanus toxin binds to presynaptic membranes and is internalized by nerves. The toxin is then transported to the central nervous system through retrograde axonal transport within the neuron. In the CNS, the toxin blocks neurotransmitter release leading to the muscle spasms characteristic of tetanus.
Molecular Weight: 150 kD
Structure: Two subunits, one heavy chain of 100 kD and a light chain of 50 kD joined by a disulfide bond.
Storage: Store at 2-8^oC.   Mix well just before use.
Activity: Maximum T cell stimulation observed at 1 ug/mL.
Note:This preparation includes alum. It is suitable for in vitro stimulation of immune cells but may not be suitable for other uses.
References: Alan W. Bernheimer, ed. Perspectives in Toxinology, c.1977 Wiley, New York.
 
FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.

This is a peptide from the Wilms Tumor antigen, WT1. The sequence is RMFPNAPYL.