Human Naïve CD4+ T Cells

Naïve CD4 T cells have differentiated from bone marrow, and have successfully undergone the central tolerance processes of positive and negative selection in the thymus. They are considered mature but inactivated, responding to novel pathogens in the immune system and initiate the immune response. They are used to elicit brand new immune responses in in vitro and in vivo studies. Naïve CD4+ T cells are isolated from leukopaks by either positive or negative selection (NS) using immunomagnetic cell separation procedures.