Human Naïve CD3+ T Cells
A naïve T cell is a mature T cell that has differentiated in the bone marrow. Unlike memory T cells, naïve T cells have not acquired an activated phenotype, therefore naïve T cells can respond to unfamiliar pathogens that have not been previously encountered and initiate an immune response. As a result, these naïve T cells can acquire the phenotype and ultimately differentiate into a memory T cell.
Naïve T cells are isolated by depleting CD45RO+ cells via immunomagnetic bead separation from a freshly collected leukopheresis product. Naïve T cells are phenotypically classified as CD45+, CD3+, and CD45RA+.