Human Dendritic Cells

Dendritic cells play a major role in the initiation of immune responses as they act as messengers between the innate and adaptive immune systems. The main function of dendritic cells is to process and present antigens on the cell surface of T cells. In addition, dendritic cells contribute to the maintenance of B cell function and recall responses. Dendritic cells are derived from purified monocytes. CD14 monocytes are positively selected and are cultured in the presence of GM-CSF and IL-4 for 7 days; and then harvested.