Tetanus toxoid is an inactivated form of tetanus toxin. Tetanus toxin is an exotoxin produced by Clostridium tetani and is the agent responsible for “lockjaw”;. Tetanus toxin binds to presynaptic membranes and is internalized by nerves. The toxin is then transported to the central nervous system through retrograde axonal transport within the neuron. In the CNS, the toxin blocks neurotransmitter release leading to the muscle spasms characteristic of tetanus.
Molecular Weight: 150 kD
Structure: Two subunits, one heavy chain of 100 kD and a light chain of 50 kD joined by a disulfide bond.
Storage: Store at 2-8oC. Mix well just before use.
Activity: Maximum T cell stimulation observed at 1 ug/mL.
Note:This preparation includes alum. It is suitable for in vitro stimulation of immune cells but may not be suitable for other uses.
References: Alan W. Bernheimer, ed. Perspectives in Toxinology, c.1977 Wiley, New York.
FOR RESEARCH USE ONLY. NOT FOR DIAGNOSTIC OR THERAPEUTIC USE.