Cell Sourcing for Research and GMP Human Cells

Charles River is an experienced cell sourcing provider of research-use and GMP-compliant human immune cells for cell and gene therapies. Our peripheral blood portfolio includes whole blood products, leukopaks, PBMCs, isolated immune cells, and stem cells. We also offer bone marrow and cord blood products. Our custom services include functional immune cell assays, proof-of-concept experiments, custom protocols, and product development.

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Browse our Cell Sourcing Products and Services

Human Peripheral Blood Products

Whole blood products, leukopaks, mobilized leukopaks, PBMCs, isolated cells (T cells, B cells, NK cells), and other primary immune cell populations to support your research efforts.

Human Stem Cells

Our human stem cell products include mobilized leukopaks, bone marrow, cord blood, hematopoietic stem cells, mesenchymal stem cells, wild-type and diseased embryonic stem cells, along with wild-type and genetically modified iPSCs with FailSafe® safety-switch technology.

GMP-compliant Cellular Starting Materials

Cell sourcing for leukopaks or bone marrow aspirate as cellular starting material that adheres to strict CGMP requirements for cell and gene therapies.

Diseased State Biospecimens

Our cell sourcing capabilities include whole blood products (serum and plasma), apheresis products (leukopaks, PBMCs, and isolated immune cells), and fluids collected from patients undergoing treatments for various disease types.

Biopreservation, Cell Freezing Media, and Antigens

CryoStor® cell freezing media and Hypothermosol® for short-and-long term storage of cellular material. Antigens for basic research applications.

Animal Primary Cells

Murine mast cells, bone marrow cells, dendritic cells, macrophages, and spleen cells, as well as bovine chondrocytes, to complement our human cell populations.

Custom Immune Cell and Donor Recruitment Services

Our scientific team has extensive experience with customized immune cell assay development, as well as product and protocol development.
Targeted Donor Selection and Sourcing

Cell Processing and Isolation Solutions

Achieve your project goals faster with our cell isolation and cryopreservation expertise. Our cell sourcing capabilities include on-site collections with same-day processing, carefully optimized protocols, and rigorous QC testing to rapidly deliver pure, viable, consistent, and highly functional cellular starting material to quickly advance your project through its product development pipelines.
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Cell Processing and Isolation Solutions

Targeted Donor Selection and Sourcing

Ensure consistent access to recallable donors throughout your cell therapy program. With over 40 years of experience building long-term donor relationships, HemaCare Donor Center (a Charles River company) has built a vast network of well-characterized donors that are readily available for the development of autologous and allogeneic cell-based therapies.
Learn About Donor Recruitment

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Cell Cryopreservation: Advantages for Cellular Starting Material

Starting material and immune cell stability is one of the most critical factors behind the success of any immunotherapy product. Cell cryopreservation is an important tool for managing variability associated with starting material stability, locking in viability and potency, and provides researchers with reliable, on-demand cellular starting material for next-generation cell and gene therapies.
Learn About Cell Cryopreservation

 

Quality Standards

  • Licensure and Accreditation

    Charles River complies with documented procedures governing the sourcing, handling, processing, storage, preserving, packaging, and distribution of products. Charles River is FDA registered (Blood and HCT/P) and meets all applicable GMP/GTP standards (21 CFR 210, 211, 606, 1271 and 21 CFR part 11 and part 58). Charles River also ensures that all sites including Lowell (Blood and HCT/P) and Memphis (Blood and HCT/P) are FDA-registered. Charles River maintains compliance with the State of California Laws and Regulations for production of biologics and tissue banking, meets CLIA requirements to ensure the accuracy and reliability of quality control testing and is AABB-accredited, which verifies that an appropriate quality management system and controlled collection processes are in place. In addition to the FDA, Charles River complies with European Medicines Agency (EMA) guidelines and our GMP-compliant facility is routinely audited by the FDA, State of California, and AABB.

  • Terms & Conditions

    Pricing is subject to Terms and Conditions – Cell Sourcing.

  • How to Order

    Please see How to Order – Cell Solutions.

 

Nurse in drop-in department or clinic taking blood from woman donor

10 Questions to Ask Your Apheresis Provider
The link between a consistent cell supply and successful cell therapies to learn how a large, diverse donor pool gives researchers access to project-specific physiological or demographic traits and more.
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