When stimulated in vitro with CMV lysate antigen, these CD4+ T cells show a specific proliferative response along with secretion of IFN-gamma, IL-5 and IL-13, but not IL-10. A majority of the T cell population are CD45RO+, CD45RA-, CD62L+, CD127+ and CD28+.
Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F
These are CD8+ T cells specific for the E7 protein of human papilloma virus. The antigenic peptide sequence is YMLDLQPET representing residues 11-19 of the protein and it is presented by the HLA-A*02:01 allele.
This donor is CMV positive and Fc gamma RIIIa F/F. She is 5′ 3″ tall and weighs 180 lbs.
Tyrosinase is a protein involved in melanin synthesis pathway. It is expressed in melanocytes, and both primary and metastatic melanoma cells. This anti-Tyrosinase T cells are CD8+ T cells with specificity to the Tyrosinase (368-376, Asp370) peptide (YMDGTMSQV), restricted by HLA-A*0201.
Donor is 5′ 6″ tall and weighs 230 lbs. She has allergies to sulfa drugs and takes Synthroid for thyroid problem. She is F/F at Fc gamma RIII alpha 158.