Research and GMP-compliant Human Cells

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When stimulated in vitro with CMV lysate antigen, these CD4+ T cells show a specific proliferative response along with secretion of IFN-gamma, IL-5 and IL-13, but not IL-10. A majority of the T cell population are CD45RO+, CD45RA-, CD62L+, CD127+ and CD28+.

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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This T cell population specifically recognizes an HLA-B35 restricted CMV pp65 peptide (IPSINVHHY) as shown by tetramer binding as well as IFN-gamma secretion assays.

Healthy young donor taking no medications. He is CMV seropositive and Fc gamma RIIIa F/F.

Additional Donor Information:

This T cell population specifically recognizes an HLA-B35 restricted CMV pp65 peptide (IPSINVHHY) as shown by tetramer binding as well as IFN-gamma secretion assays.

Healthy young donor taking no medications. He is CMV seropositive and Fc gamma RIIIa F/F.

Additional Donor Information:

This T cell population specifically recognizes an HLA-B35 restricted CMV pp65 peptide (IPSINVHHY) as shown by tetramer binding as well as IFN-gamma secretion assays.

Healthy young donor taking no medications. He is CMV seropositive and Fc gamma RIIIa F/F.

Additional Donor Information:

This T cell population specifically recognizes an HLA-B35 restricted CMV pp65 peptide (IPSINVHHY) as shown by tetramer binding as well as IFN-gamma secretion assays.

Healthy young donor taking no medications. He is CMV seropositive and Fc gamma RIIIa F/F.

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Healthy female donor, CMV negative. 5′ 10″ tall, 210 lbs. Her genotype at Fc gamma RIII alpha 158 is F/V.

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Donor is healthy. He is 5′ 3″ tall and weighs 240 lbs. He has seasonal allergies and is allergic to cats and dogs. He is taking metformin and is CMV positive. His Fc gamma RIIIa genotype is F/V.

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Donor is allergic to dogs and penicillin. He smokes 2 cigarettes per day. His Fc gamma RIII alpha genotype is F/V

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These are CD8+ T cells specific for the E7 protein of human papilloma virus. The antigenic peptide sequence is YMLDLQPET representing residues 11-19 of the protein and it is presented by the HLA-A*02:01 allele.

This donor is CMV positive and Fc gamma RIIIa F/F. She is 5′ 3″ tall and weighs 180 lbs.

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T cell population reactive to an HLA-A0201-restricted HPV E7 peptide from position 82-90 (LLMGTLGIV)

This donor is CMV positive and Fc gamma RIIIa F/F. She is 5′ 3″ tall and weighs 180 lbs.

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T cell population reactive to an HLA-A0201-restricted HPV E7 peptide from position 82-90 (LLMGTLGIV)

This donor is CMV positive and Fc gamma RIIIa F/F. She is 5′ 3″ tall and weighs 180 lbs.

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These T cells recognize a peptide from glycoprotein D1 [gD1(53-61): SLPITVYYA] of Herpes simplex virus (HSV) presented by HLA-A*0201.

Donor is 5′ 6″ tall and weighs 230 lbs. She has allergies to sulfa drugs and takes Synthroid for thyroid problem. She is F/F at Fc gamma RIII alpha 158.

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These cells are specific for the peptide sequence GILGFVFTL, found in the matrix protein of influenza virus. The peptide is presented (bound by) HLA-A*0201

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

Additional Donor Information:

These cells are specific for the peptide sequence GILGFVFTL, found in the matrix protein of influenza virus. The peptide is presented (bound by) HLA-A*0201

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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MART-1 (Melanoma Antigen Recognized by T cells), also known as Melan-A, is a 118 amino acid long surface protein expressed mainly on melanocytes and most melanoma. This anti MART-1 T cells are CD8+ T cells with specificity to the naturally processed native MART-1 (27-35) 9-mer: AAGIGILTV. These T cells also recognize the analog peptide: ELAGIGILTV, a 10-mer (26-35) with L for A substitution in position 27.

Donor is 5′ 6″ tall and weighs 230 lbs. She has allergies to sulfa drugs and takes Synthroid for thyroid problem. She is F/F at Fc gamma RIII alpha 158.

Additional Donor Information:

MART-1 (Melanoma Antigen Recognized by T cells), also known as Melan-A, is a 118 amino acid long surface protein expressed mainly on melanocytes and most melanoma. This anti MART-1 T cells are CD8+ T cells with specificity to the naturally processed native MART-1 (27-35) 9-mer: AAGIGILTV. These T cells also recognize the analog peptide: ELAGIGILTV, a 10-mer (26-35) with L for A substitution in position 27.

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An HLA-A*0201-restricted T cell line with the specificity for the KLPDDFTGCV, a peptide that corresponds to the Spike protein (position 424-433) of the novel coronavirus SARS-CoV-2.

Healthy CMV seropositive female non-smoker. She takes Flonase for seasonal allergies. Genotype at FcgRIIIa is F/F

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These CD4+ T cells are specific for a peptide (QYIKANSKFIGITEL) derived from tetanus toxoid bound to HLA-DRB1*01. They also recognize whole tetanus toxoid but only when presented by dendritic cells, not B-LCL.
The T cells proliferate when stimulated with antigen and APC. They also produce IFNg, IL-5, IL-10, and IL-13.

Healthy female donor, CMV negative. 5′ 10″ tall, 210 lbs. Her genotype at Fc gamma RIII alpha 158 is F/V.

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Tyrosinase is a protein involved in melanin synthesis pathway. It is expressed in melanocytes, and both primary and metastatic melanoma cells. This anti-Tyrosinase T cells are CD8+ T cells with specificity to the Tyrosinase (368-376, Asp370) peptide (YMDGTMSQV), restricted by HLA-A*0201.

Donor is 5′ 6″ tall and weighs 230 lbs. She has allergies to sulfa drugs and takes Synthroid for thyroid problem. She is F/F at Fc gamma RIII alpha 158.

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This population contains >20% CD8 T cells specific to the WT-1 (Wilm’s Tumor gene product) peptide RMFPNAPYL (aa 126-134) presented by HLA-A*0201. WT-1 protein is overexpressed in leukemia and various solid cancers.

Donor has an allergy to kidney beans and seasonal allergies. She does not take any medications and does not smoke. She has the V/V genotype for FcgRIII alpha